Travel & Accomodation info for IV season

Hello Friends,
I and a few of my female friends are concerened about limited travel & transportation info. In a couple of months, we would be travelling hopefully. People from last year, if you would like to share info and your experience that would be great.
So far my search is for the northeast area of USA. Instead of flying between nearby states you have options like peterpan buses, amtrak, greyhound but im not sure about the rates and if they are safe enough. Not many hospitals will provide/pay for accomodation so we have to look into that too. Best would be a relative or friend. Not many of us will be willing to rent a car in a new city so cabs will come in handy but can be really expensive.
So plz share any information you guys have.
Thank you.